The Sperm Aneuploidy Test (SAT) is a diagnostic test to study the genetic etiology of male infertility.
It allows for the evaluation of the presence of an abnormal number of chromosomes (aneuploidy and diploidy) in the sperm.
The chromosomes 13, 18, 21, X and Y, mostly implicated in spontaneous miscarriages and affected offspring with chromosomal abnormalities, are analyzed by fluorescence in situ hybridization.
An increase of sperm chromosomal abnormalities affects three levels:
EMBRYO LEVEL:
Rodrigo et al., 2010.
PREGNANCY LEVEL:
Rubio et al., 2001.
OFFSPRING LEVEL:
Rodrigo L, Peinado V, Mateu E, Remohí J, Pellicer A, Simón C, Gil-Salom M, Rubio C. Impact of different patterns of sperm chromosomal abnormalities on the chromosomal constitution of preimplantation embryos. Fertil Steril. 2010 Sep; 94(4):1380-6.
Rubio C, Gil-Salom M, Simón C, Vidal F, Rodrigo L, Mínguez Y, Remohí J, Pellicer A. Incidence of sperm chromosomal abnormalities in a risk population: relationship with sperm quality and ICSI outcome. Hum Reprod. 2001 Oct; 16(10):2084-92.
Rodrigo L, Mateu E, Mercader A, Cobo A, Peinado V, Milán M, Al-Asmar N, Campos-Galindo I, García-Herrero S, Mir P, Simón C, Rubio C. New tools for embryo selection: comprehensive chromosome screening by array comparative genomic hybridization. BioMed
Research International. 2014; In Press.
染色体に異常のない胚を 子宮に戻すことで出産率が向上します（日本産婦人科学会のガイドラインを遵守します)
着床不全を防ぐために女性の子宮内膜の
着床能の状態を評価します
